Polychlorinated Biphenyls Profile

INDUSTRIAL CHEMICALS  KNOWN CARCINOGEN (IARC 1)

CAS No. 1336-36-3
IARC Monograph Vol. 100F, 2012 (Group 1)
IARC Monograph Vol. 107, 2016 (Group 1)

Polychlorinated Biphenyls Profile

General Information

Polychlorinated biphenyls (PCBs) are a group of chemicals made up of 209 isomers.[1] Synthetic compounds, they are similar in structure but vary considerably in their physical properties.[1,2] PCBs may be oily liquids or solids that are colourless to white, depending on the exact chemical make-up.[1] They are very stable and persist in the environment.[3] Polychlorinated biphenyls may also be referred to as chlorobiphenyls, chlorinated biphenyls or Aroclor, a commercial name.[4] There are numerous other synonyms and product names; see the Hazardous Substances Data Bank (HSDB) for more information.[4]

PCBs as a group have been classified by the International Agency for Research on Cancer (IARC) as Group 1, carcinogenic to humans.[5] This classification is based on consistent associations between PCB exposure and increased risk of melanoma in humans.[5] There is also limited evidence from some studies suggesting that exposure is linked to increased risks of non-Hodgkin lymphoma and breast cancer.[5] The first PCB classified by IARC was 3,3′,4,4′,5-pentachlorobiphenyl (PCB-126); it was classified in 2012 as Group 1, based on strong mechanistic evidence for genotoxicity.[6]

PCB exposure may irritate the skin and at high levels can cause liver damage.[7] Stored in fatty tissues, PCBs can build up to concentrations far exceeding those found in the environment.[7] Little is known about the long-term health impacts of exposure to PCBs, since most observed health effects have resulted from short-term and high-level accidental or occupational exposures.[2]

Regulations and Guidelines

Occupational exposure limits (OEL)[8,9,10,11,12,13,14,15,16,17,18,19,20,21,22]

Canadian JurisdictionsOEL (mg/m3)
Canada Labour Code1 [42% Cl, sk]
0.5 [54% Cl, sk]
AB, BC, MB, NB, NL, NS, PE, QC1 [42% Cl, sk]
0.5 [54% Cl, sk]
QC1 [42% Cl, sk, em]
0.5 [54% Cl, sk, em]
YT1 [42% Cl, sk]; 2 [stel, sk]
0.5 [54% Cl, sk]; 1 [stel, sk]
ON0.05
NU, SK, NT1 [42% Cl, sk]; 3 [stel, sk]
0.5 [54% Cl, sk]; 1.5 [stel, sk]
Other JurisdictionOEL (mg/m3)
ACGIH 2020 TLV1 [42% Cl, sk]
0.5 [54% Cl, sk]
mg/m3 = milligrams per cubic meter
Cl = chlorine
sk = easily absorbed through the skin
stel = short term exposure limit (15 min. maximum)
em = exposure must be reduced to the minimum
ACGIH = American Conference of Governmental Industrial Hygienists
TLV = threshold limit value
All exposure limits are defined in the legislation as chlorodiphenyl except for Ontario that defines the limit as polychlorinated biphenyls.

Canadian environmental guidelines and standards*

JurisdictionLimitYear
Canadian Drinking Water GuidelinesArchived**2008[23]
Ontario Drinking Water Standards0.003 mg/L2003[24]
Ontario Ambient Air Quality Criteria24 hour: 0.15 µg/m32016[25]
Annual: 0.035 µg/m32012[25]
BC’s Contaminated Sites Regulation, BC Reg 375/96Sets soil standards for the protection of human health:
Agricultural and low density residential sites: 5 μg/g
Urban park and high density residential sites: 10 μg/g
Commercial sites: 35 μg/g
Industrial sites: 900 μg/g
2017[26]
µg/L = micrograms per litre
µg/m3 = micrograms per cubic meter
µg/g = micrograms per gram
IMAC = interim maximum allowable concentration
*Standards are legislated and legally enforceable, while guidelines (including Ontario ambient air quality criteria) describe concentrations of contaminants in the environment (e.g. air, water) that are protective against adverse health, environmental, or aesthetic (e.g. odour) effects
**Health Canada defines archived parameter as “parameters which are no longer found in Canadian drinking water supplies at levels that could pose a risk to human health, including pesticides which are no longer registered for use in Canada, and for mixtures of contaminants that are addressed individually.”

 

Canadian agencies/organizations

AgencyDesignation/PositionYear
Health CanadaDSL – low priority substance (previously assessed/risk managed)2006[27]
CEPASchedule 1, paragraphs ‘a’, ‘b’, and ‘c’2012[28]
National Classification System for Contaminated SitesRank = “High hazard”2008[29]
Canada-Ontario Agreement on Great Lakes Water Quality and Ecosystem HealthTier 1 chemical: targeted for virtual elimination2014[30]
DSL = domestic substance list
CEPA = Canadian Environmental Protection Act

Polychlorinated biphenyls were not included in other Canadian government guidelines, standards, or chemical listings reviewed.

Main Uses

The stable, relatively fire-resistant, and non-corrosive properties of PCBs have made them useful in a wide range of applications.[31] Historically, PCBs were used extensively to make industrial materials such as sealing and caulking compounds, cutting oils, inks, and paint additives.[32] They were also used to produce coolants and lubricants for certain kinds of electrical equipment, such as transformers and capacitors.[32]

Historically in Canada, PCBs were widely used to manufacture electrical equipment, heat exchangers, hydraulic systems, and several other specialized applications.[33]

According to Canadian legislation from 1980 and 1985, the only permissible use of PCBs is in older equipment, such as refrigerators, until the end of that equipment’s service life.[33,34] The maximum allowable concentration of PCBs per equipment is 50 parts per million by weight.[34] The equipment must have been designed to use PCBs at the time that it was imported, manufactured or knowingly offered for sale.[34]

There was a 72% decrease in the amount of PCBs used or stored in Canada from 2012 to 2014. In 2014, 111 tonnes of PCBs were stored, 51 tonnes were in use, and 716 tonnes were destroyed.[35]

Canadian Production and Trade

Canada has never manufactured PCBs, but imported approximately 40,000 tonnes annually from 1929 until the 1970s.[31]

In 2002, the Canadian Working Group, Great Lakes Binational Toxics Strategy, classified three major industry sectors that needed to be targeted for PCB destruction, due to high levels of PCB storage. They include provincial and municipal governments, iron and steel manufacture, and forestry, pulp, and paper industries.[36,37]

In 2008, legislative efforts concentrated on preventing further production of PCBs, contamination of the environment, and destruction of currently stored PCBs.[34] Standardized waste management procedures have been developed[38] and many companies specialize in PCB disposal.[39]

Production and trade

ActivityQuantityYear
Export72 kg of ‘mixtures and preparations containing polychlorinated biphenyls PCBs, PCTs or PBBs’2011[40]
Import0 kg of ‘mixtures and preparations containing polychlorinated biphenyls PCBs, PCTs and PBBs’2011[40]
kg = kilogram
PCT = polycyclohexylenedimethylene terephthalate
PBB = polybrominated biphenyls

Environmental Exposures Overview

Inhalation, dermal contact, and ingestion are potential routes of exposure to PCBs for the general population.[1] All Canadians have PCBs in their bodies due to exposure to small amounts present in food, air, soil, and water.[32] The greatest source of PCB exposure for Canadians is consuming contaminated foods.[32,41]

Due to PCBs’ persistence and bioaccumulation potential, the highest concentrations are found in animals at the top of the food chain.[32] Foods found to contain high concentrations of PCBs include fish (particularly sport fish caught in contaminated lakes or rivers), meat, and poultry.[3] A survey on PCB concentrations in food, conducted in Vancouver in 2002, found that freshwater fish and marine fish carried the highest concentrations of PCBs.[42,43] A 2004 Canadian study of farmed fish found higher PCB levels in farmed versus wild salmon; however, the contaminant levels in farmed fish were still less than 1/80th of the acceptable level established by Health Canada.[44]

According to Health Canada, the average daily dietary intake of PCBs is estimated to be less than ½ a millionth of a gram.[32] Individuals who consume large amounts of fish, wildlife, or marine mammals may be exposed to higher concentrations.[32] Infants may also be exposed to PCBs through breast milk.[3] A study looking at over 300 breast milk samples collected between 1992 and 2005 across Canada found that median levels of PCBs declined significantly between 2002-2005.[45] This was at the lower end of the concentration range reported in industrialized nations.[46] CAREX Canada estimates that PCB levels in food and beverages result in an increased risk of cancer in Canada (very low data quality).

PCBs have been found in runoff, sediment, soil, rivers, creek water, lakes, leachate, pond effluents, landfills, and an underground oil-water layer.[1,47] There are no known natural sources of PCBs in the environment:[41] the widespread prevalence of PCBs in the environment is due to prior industrial use and their environmental persistence.[1] A 2007 study investigated PCB levels in Ontario rain, snow and surface waters.[48] All samples were positive for PCBs. Concentrations varied between urban and rural areas; greater concentrations were found in urban areas. However, PCBs are still found in remote areas of Canada due to long-range transport by global air currents.[32] Currently, there is insufficient measured data for CAREX Canada to produce environmental exposure estimates for PCBs in drinking water (data gap).

CAREX Canada estimates that PCB levels in outdoor air is negligible, however, PCB levels in indoor air result in an increased risk of cancer (data quality very low). In addition, we estimate that PCB levels in indoor dust do not result in an increased risk of cancer (data quality very low).

PCB release is not reportable to the National Pollutant Release Inventory in Canada.[49] No household products containing PCBs were listed in the Household Products Database from the United States.[50]

For more information, see the environmental exposure estimate for polychlorinated biphenyls.

Occupational Exposures Overview

Inhalation, dermal absorption and ingestion are all potential routes of occupational exposure to PCBs.[1]

CAREX Canada estimates that approximately 8,00 Canadians are exposed to polychlorinated biphenyls in their workplaces. The largest industrial groups exposed are building equipment contractors (e.g. electricians) and electric power generation, transmission, and distribution. Other important industries exposed to PCBs are utility system construction, public administration, and foundation, structure, and building exterior contractors.

The largest occupational groups exposed to PCBs include industrial electricians, contractors and supervisors in electrical and telecommunication trades, electrical power line and cable workers, and electrical mechanics. Other occupational exposures may occur in workers involved in waste storage and incineration, and contaminated site remediation.[3,32] Welders and general maintenance workers in various industries may also encounter PCBs in old industrial paints and coatings.[3] Exposure may also occur during accidental spills or fires involving equipment containing PCBs.[1,7]

For more information, see the occupational exposure estimate for polychlorinated biphenyls.

Sources

Photo: Wikimedia Commons, Sturmovik

1. National Toxicology Program (NTP). 14th Report on Carcinogens for Polychlorinated Biphenyls (2016) (PDF)
2. Government of Canada. Chemical Substances, PCBs (2007)
3. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Polychlorinated biphenyls (PCBs) (2000) (PDF)
4. US National Library of Medicine. Hazardous Substances Data Bank (HSDB) (Search term: ‘Polychlorinated Biphenyls’)
5. Lauby-Secretan B, Loomis D, Grosse Y, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Baan R, Mattock H, Straif K; WHO International Agency for Research on Cancer. “Carcinogenicity of polychlorinated biphenyls and polybrominated biphenyls.” Lancet Oncol 2013;14:287-288.
6. International Agency for Research on Cancer (IARC). Monograph summary, Volume 100 Part F (2012) (PDF)
7. Agency for Toxic Substances and Disease Registry (ATSDR). ToxFAQs Fact Sheet – Polychlorinated biphenyls (2001) (PDF)
13. Government of Newfoundland and Labrador. Regulation 5,12 Occupational Health and Safety Regulations (2018)
14. Government of the Northwest Territories. Occupational Health and Safety Regulations, R-039-2015 (2020) (PDF)
16. The Canadian Legal Information Institute (CanLII). Government of Nunavut’s Occupational Health and Safety Regulations, Nu Reg 003-2016 (2010)
18. Government of Prince Edward Island. Occupational Health and Safety Act Regulations Chapter 0-1 (2013) (PDF)
20. Government of Saskatchewan. The Occupational Health and Safety Regulations, 1996 (2016) (PDF)
21. The Canadian Legal Information Institute (CanLII). Yukon’s Occupational Health Regulations, O.I.C. 1986/164 (2020) (PDF)
22. Occupational Safety and Health Administration (OSHA). Annotated PELs (2020)
24. The Canadian Legal Information Institute (CanLII). Ontario Drinking Water Quality Standards, O Reg 169/03 (2020)
25. Ontario Ministry of the Environment and Climate Change. Ontario’s Ambient Air Quality Criteria (2019)
26. Government of British Columbia. Contaminated Sites Regulation B.C. Reg. 375/96 (2019)
28. Environment and Climate Change Canada. Toxic Substances List under CEPA (2012)
29. Health Canada. Cosmetic Ingredient Hotlist (2019)
31. Government of Canada. Environmental Health: Risks Posed by PCBs (1994)
32. Health Canada. It’s Your Health: PCBs (2011) (PDF)
34. Ministry of Justice. PCB Regulations (2006) (2006)
35. Environment and Climate Change Canada. PCB Program/Environmental Protection Branch representative (A.L)
36. US Environmental Protection Agency (EPA). Great Lakes Binational Toxics Strategy (2012)
37. US Environmental Protection Agency (EPA) and Government of Canada. Annual Process Report – Great Lakes Binational Toxics Strategy (2007)
38. University of Toronto – Environmental Health and Safety. PCB Wastes Procedures (2004)
39. PCB Disposal Inc. Company Bio (2009)
40. International Trade Centre. TradeMap (Free subscription required)
42. Health Canada. Food and Nutrition: PCBs (2008)
43. Health Canada. Total Diet Survey, PCBs – Vancouver (2002) (PDF)
44. Fisheries and Oceans Canada. Aquaculture Update (2007) (PDF)
46. Dewailly E, Ayotte P, Laliberté C, et al. “Polychlorinated biphenyl (PCB) and dichlorodiphenyl dichloroethylene (DDE) concentrations in the breast milk of women in Quebec.” American Journal of Public Health 1996;86:1241-1246.
47. International Programme on Chemical Safety (IPCS) INCHEM. CICAD Document 55 for PCB’s: Human Health Aspects (2003)
48. Ueno D, Darling C, Alaee M, Campbell L, Pacepavicius G, Teixeira C, Muir D. “Detection of hydroxylated polychlorinated biphenyls (OH-PCBs) in the abiotic environment: Surface water and precipitation from Ontario, Canada.” Environ Sci Technol2007;41:1841-1848.
49. Environment and Climate Change Canada. National Pollutant Release Inventory (NPRI) Facility Search (Substance name: ‘Polychlorinated Biphenyls’)
50. US Household Products Database (HPD). Household Products (Search term: ‘Polychlorinated biphenyls’)

   

Other Resources

  1. Health Canada. Total Diet Survey Study Publication Page (2016)

Subscribe to our newsletters

The CAREX Canada team offers two regular newsletters: the biannual e-Bulletin summarizing information on upcoming webinars, new publications, and updates to estimates and tools; and the monthly Carcinogens in the News, a digest of media articles, government reports, and academic literature related to the carcinogens we’ve classified as important for surveillance in Canada. Sign up for one or both of these newsletters below.

CAREX Canada

Faculty of Health Sciences

Simon Fraser University
Harbour Centre Campus
2602 - 515 West Hastings St
Vancouver, BC  V6B 5K3
CANADA

© 2021 CAREX Canada