MCPP Profile

MCPP Profile

QUICK SUMMARY

  • A pesticide used in agriculture, and on ornamental plants and turf
  • Associated cancers: Non-Hodgkin lymphoma, soft-tissue sarcoma (limited evidence)
  • Most important route of exposure: Inhalation, skin contact
  • Uses: Weed control in agriculture (on wheat, barley oats, rye, and corn) and on ornamental plants, sports turf, forest sites, and drainage ditch banks
  • Occupational exposures: Via manufacturing, applying, and disposing of MCPA
  • Environmental exposures: Contaminated drinking water, food, and air after MCPP application
  • Fast fact: Use of MCPP is decreasing in many countries, including Canada.

General Information

2-(2-Methyl-4-chlorophenoxy) propanoic acid (MCPP) is a colourless or white to tan crystalline powder that is soluble in water.[1] MCPP is a member of the chlorophenoxy herbicide group, which also includes MCPA and 2,4-D, among others.[1] MCPP may be referred to by its trade names, most notably Mecoprop®.[2] MCPP is not currently registered for use in Canada by the Pest Management Regulatory Agency (PMRA).[3] There are numerous other synonyms and product names; see Hazardous Substances Data Bank (HSDB) for more information.[1]

Chlorophenoxy herbicides, which include MCPP, have been classified by the International Agency for Research on Cancer (IARC) as Group 2B, possibly carcinogenic to humans. This classification is based on limited evidence of carcinogenicity in humans and insufficient evidence in experimental animals.[4] While the epidemiological studies reviewed by IARC suggested associations between exposure to the chlorophenoxy herbicides and non-Hodgkin lymphoma (NHL) as well as soft-tissue sarcoma, the studies had several limitations and results were inconsistent.[4] MCPP has not been evaluated by IARC in nearly 20 years. More recent studies support the association between MCPP or chlorophenoxy herbicides and NHL, soft-tissue sarcoma, or multiple 
myeloma.[5,6,7,8,9] The US EPA evaluated MCPP in 2007 and concluded that the evidence was suggestive of carcinogenicity, but was insufficient to assess human carcinogenic potential.[10]

Other health effects of acute exposure to MCPP include fever, respiratory problems, and kidney damage.[11] It is not known whether MCPP exposure has reproductive health effects in humans.[11,12]

Regulations and Guidelines

No occupational exposure limits for MCPP were found for Canada or any international bodies.[13,14,15,16,17,18,19,20,21,22,23,24,25,26,27]

Canadian Environmental Guidelines

Jurisdiction Limit Year
WHO Drinking Water Guideline 10 µg/L 2003[11]
Maximum Residue Limit Meat by-products (cattle, poultry, hogs, horses, sheep, goats): 0.05 ppm
Animal fat and meat: 0.02 ppm
Cereals: 0.02 ppm
Milk: 0.01 ppm
2018[28]
BC’s Contaminated Sites Regulation, BC Reg 375/96 Sets soil standards for the protection of human health:
Agricultural and low density residential sites: 15 μg/g
Urban park and high density residential sites: 130 μg/g
Commercial and industrial sites: 250 μg/g
Drinking water standards: 4 μg/L
2017[29]
µg/L = micrograms per litre
ppm = parts per million
μg/g = micrograms per gram

MCPP was not included in other Canadian government environmental guidelines reviewed.[30,31]

Canadian Agencies/Organizations

MCPP was not included in the Canadian government chemical listings reviewed.[32,33,34,35,36]

Main Uses

MCPP has been produced since the 1950s for agricultural and defoliant purposes. MCPP production and use in many countries is now decreasing.[12] MCPP is a general use, selective phenoxy herbicide.[2] It works slowly and is absorbed by plant leaves, where it affects growth and enzyme activity.[2]

MCPP is available as a liquid concentrate or granules, and can be sprayed on fertilizer pellets.[2] It is used on ornamental plants and sports turf, for forest site preparation, and on drainage ditch banks to selectively control surface broadleaf weeds such as clovers, chickweed, ivy, plantain, and others.[2] MCPP can also be used in agriculture on wheat, barley, oats, rye, and corn.[37]

Canadian Production and Trade

Although Canada engages in international trade of herbicides, MCPP was not listed in TradeMap for trade commerce for Canada.[38]

Environmental Exposures Overview

Sources of environmental exposure include contaminated water, food, and air. These exposures are a consequence of direct application of chlorophenoxy herbicides in agricultural and non-agricultural areas.[11] The half-life of MCPP in soil is approximately three weeks; the half-life in water is not available.[39]

Pesticide residue testing was completed between 2006 and 2011 in the Nelson Watershed in Manitoba; MCPP was detected in 60% of samples collected from the Red River sampling station, with a maximum of 59 ng/L.[40]

Release of MCPP is not reportable to Environment Canada’s National Pollutant Release Inventory (NPRI).[41] A search of the Household Products Database yielded the following results on current potential for exposure to MCPP (though this resource is based in the US):

US Household Products Database

US Household Products 2016[42]
Search Term Quantity Product Type
“MCPP” 10 Weed killers(9), lawn fertilizer(1)

A summary of environmental concentration data is available here [PDF].

Occupational Exposures Overview

Inhalation and dermal absorption are the most important routes of occupational exposure to MCPP.[12]

Occupational exposure can occur while producing, formulating, applying, and disposing of MCPP.[12] High level exposures in the workplace can occur as a result of accidents, such as spills.[12] Particular tasks where exposure to MCPP may occur include ground spraying and manual application of herbicides containing MCPP, as well as handling raw materials, intermediates, and finished products during pesticide manufacture. Waste processing is another task where exposure to MCPP may take place.[12]

Limited research exists on occupational exposure to MCPP specifically, even among farm workers. The majority of occupational research considers total chlorophenoxy herbicide exposure, or has singled out exposure to 2,4-D and/or MCPA specifically.

CAREX Canada has not prioritized MCPP for exposure estimate development. This is because a lack of exposure data precluded it in the past. However, the team is investigating new sources of data and methods in order to potentially address this exposure in the future.

Sources

1. US National Library of Medicine. Hazardous Substances Database (HSDB) (Search term: ‘MCPP’)
2. Extension Toxicology Network (EXTOXNET). Pesticide Information Profiles: Mecoprop (1995)
3. Health Canada. Pesticide Label Search (Search term: ‘MCPP’) (2016)
4. International Agency for Research on Cancer (IARC). Monograph summary, Supplement 7 (1987) (PDF)
6. Kachuri L, Demers PA, Blair A, Spinelli JJ, Pahwa M, McLaughlin JR, Pahwa P, Dosman JA, Harris SA. “Multiple pesticide exposures and the risk of multiple myeloma in Canadian men.” Intl J Cancer 2013;133(8):1846-1858.
7. Pahwa P, Karunanayake CP, Dosman JA, Spinelli JJ, McDuffie HH, McLaughlin JR. “Multiple myeloma and exposure to pesticides: a Canadian case-control study.” J Agromedicine 2012;17(1):40-50.
8. Hohenadel K, Harris SA, McLaughlin JR, Spinelli JJ, Pahwa P, Dosman JA, Demers PA, Blair A. “Exposure to multiple pesticides and risk of non-Hodgkin lymphoma in men from six Canadian provinces.” Int J Environ Res Public Health 2011;8(6):2320-2330.
9. Pahwa M, Harris SA, Hohenadel K, McLaughlin JR, Spinelli JJ, Pahwa P, Dosman JA, Blair A. “Pesticide use, immunologic conditions, and risk of non-Hodgkin lymphoma in Canadian men in six provinces.” Int J Cancer. 2012;131(11):2650-2659.
10. US Environmental Protection Agency (EPA). Reregistration Eligibility Decision (RED) for Mecoprop-p (MCPP) (2007) (PDF)
12. International Agency for Research on Cancer (IARC). Monograph summary, Volume 41 (1986) (PDF)
16. Government of Saskatchewan. The Occupational Health and Safety Regulations, 1996 (2016) (PDF)
17. The Canadian Legal Information Institute (CanLII). Yukon’s Occupational Health Regulations, O.I.C. 1986/164 (2012) (PDF)
18. Occupational Safety and Health Administration (OSHA). Annotated PELs (2018)
21. Government of Newfoundland and Labrador. Regulation 5,12 Occupational Health and Safety Regulations (2012)
22. Government of the Northwest Territories. Occupational Health and Safety Regulations, R-039-2015 (2016) (PDF)
24. The Canadian Legal Information Institute (CanLII). Government of Nunavut’s Occupational Health and Safety Regulations, Nu Reg 003-2016 (2010)
26. Government of Prince Edward Island. Occupational Health and Safety Act Regulations Chapter 0-1 (2013) (PDF)
29. Government of British Columbia. Contaminated Sites Regulation B.C. Reg. 375/96 (2017)
32. Health Canada. Prioritization of the DSL (2006)
33. Environment and Climate Change Canada. CEPA List of Toxic Substances (1999)
34. Canadian Council of Ministers of the Environment (CCME). National Classification System for Contaminated Sites (2008) (PDF)
35. International Joint Commission. Revised Great Lakes Water Quality Agreement of 1978 (1978) (PDF)
37. Regulatory Impacts, Alternatives and Strategies (RIAS) Inc. Assessment of the Economic and Related Benefits to Canada of Phenoxy Herbicides (2006) (PDF)
38. International Trade Centre. TradeMap (Free subscription required)
41. Environment and Climate Change Canada. National Pollutant Release Inventory
42. US Household Products Database (HPD). Household Products (Search term: ‘MCPP’)

Other Resources

  1. US Environmental Protection Agency (EPA). Integrated Risk Information System (IRIS), 2-(2-Methyl-4-chlorophenoxy) propionic acid (MCPP) (CASRN 93-65-2 ) (2008)

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