Arsenic and Arsenic Compounds Profile


CAS No. 7440-38-2
IARC Monograph Vol. 23, Suppl. 7, 1987 (Group 1)
IARC Monograph Vol. 84, 2004 (Arsenic in Drinking Water, Group 1)
IARC Monograph Vol 100C, 2012 (Group 1)

Arsenic and Arsenic Compounds Profile


  • A naturally occurring semi-metallic element found in complex mineral deposits
  • Associated cancers: Lung, skin, and bladder cancers (sufficient evidence); kidney, liver, and prostate cancers (limited evidence)
  • Most important route of exposure: Inhalation, ingestion
  • Uses: Preservation of wood products  including marine timbers, plywood flooring and roofing, utility poles, and glue-laminated beams; applications in glassmaking, metallurgical and semiconductor industries
  • Occupational exposures: Approx. 25,000 Canadians are exposed to arsenic at work, primarily in the wood product manufacturing and construction industries
  • Environmental exposures: Via food (including shellfish, meat, poultry, grain, and dairy products) and drinking water in areas where arsenic is found in bedrock
  • Fast fact: In 2003, a voluntary agreement was made in the United States and Canada to stop using chromated copper arsenate (CCA) for residential wood preservation.

General Information

Arsenic is a semi-metallic element. Although it is rare to find pure arsenic in nature, inorganic arsenic compounds are found in complex minerals containing copper, lead, iron, nickel, cobalt, and other elements.[1] Most arsenic compounds are white powders with no odour.[2] Of all commercially traded arsenic compounds, arsenic trioxide is the most important.[1] There are numerous other synonyms and product names for arsenic; see the Hazardous Substances Data Bank (HSDB) for more information.[3,4]

In both Monograph Volumes 23 and 84 of the International Agency for Research on Cancer (IARC), arsenic and its compounds were classified as Group 1, carcinogenic to humans. IARC’s Volume 100 review of Group 1 carcinogens in 2012 reaffirmed this classification.[5] The evaluation applies to the whole group of arsenic compounds, not necessarily to each individual compound.[3] Epidemiologic studies in occupational settings established a strong association between inhalation exposure to arsenic and lung cancer, particularly in smelting and mining industries.[2] Long-term exposure to arsenic through ingestion (i.e. medicinally, via drinking water) can cause skin cancer.[1] There is also sufficient evidence that inorganic arsenic compounds cause urinary bladder cancer.[5] Other cancer sites associated with arsenic exposure include the liver, kidney, and prostate.[5]

Chronic ingestion of arsenic is characterized by discoloured and thickened skin on hands and feet,[6] which often precedes malignancy.[2] Neurological changes including peripheral neuropathies are also reported from low dose, chronic exposure to arsenic.[2] Because of its effectiveness as a poison, there is well established data on acute exposure to arsenic resulting in death; this includes respiratory, kidney, and cardiovascular damage, as well as haematological changes.[2]

Regulations and Guidelines

Occupational exposure limits (OEL)[7,8,9,10,11,12,13,14,15,16,17,18,19,20,21]

Canadian Jurisdictions Substance OEL
Canada Labour Code Arsenic
0.01 mg/m3 [bei]
0.005 ppm
AB, NB Arsenic
0.01 mg/m3
0.05 ppm
BC Arsenic
0.01 mg/m3
0.005 ppm
MB, NL, PEI, NS Arsenic
0.01 mg/m3 [bei]
0.005 ppm
ON Arsenic
0.01 mg/m3, 0.05 mg/m3 [stel]
0.005 ppm
QC Arsenic
0.1 mg/m3
0.05 ppm
SK, NT, NU Arsenic
0.01 mg/m3, 0.03 mg/m3 [stel]
0.05 ppm, 0.15 ppm [stel]
YT Arsenic
0.5 mg/m3, 0.5 mg/m3 [stel]
0.05 ppm, 0.05 ppm [stel]
Other Jurisdiction Substance OEL
ACGIH 2020 TLV Arsenic
0.01 mg/m3 [bei]
0.005 ppm
Arsine = gaseous arsenic trihydride
bei = Jursidiction also has a biological exposure index
mg/m3 = milligrams per cubic meter
ppm = parts per million
stel = short term exposure limit (15 min. maximum)
ACGIH = American Conference of Governmental Industrial Hygienists
TLV = threshold limit value

Canadian environmental guidelines and standards*

Jurisdiction Limit Year
Drinking Water Guidelines (Canada, BC, MB) and Standards (ON, QC, SK) 0.010 mg/L, ALARA 2006-2020
Alberta Ambient Air Quality Objectives Annual: 0.01 µg/m3
1-hour: 0.1 µg/m3
Manitoba Ambient Air Quality Guideline 24-hour: 0.3 µg/m3 2005[29]
Ontario Ambient Air Quality Criteria 24-hour: 0.3 µg/m3 2016[30]
Canadian Soil Quality Guidelines for Environmental Health 12 ppm 1997[31]
Quebec’s Clean Air Regulation 1 year limit: 0.003 µg/m3; Prohibited discharge into the air if the concentration of arsenic exceeds the standard 2011[32]
BC’s Contaminated Sites Regulation, BC Reg 375/96 Sets soil standards for the protection of human health:
Agricultural and low density residential sites: 20 μg/g
Urban park and high density residential sites: 40 μg/g
Commercial sites: 150 μg/g
Industrial sites: 400 μg/g


Drinking water: 10 µg/L

List of contaminants and other adulterating substances in foods Maximum levels for total arsenic:
Fish protein: 3.5 ppm
Edible bone meal: 1 ppm
Beverages, fruit juice, fruit nectar: 0.1 ppm applied to products as consumed
Water in sealed containers: 0.01 ppm


Maximum levels for asrenic, inorganic:
Husked brown rice: 0.35 ppm
Polished white rice: 0.2 ppm

*Standards are legislated and legally enforceable, while guidelines (including Ontario ambient air quality criteria) describe concentrations of contaminants in the environment (e.g. air, water) that are protective against adverse health, environmental, or aesthetic (e.g. odour) effects

Canadian agencies/organizations

Agency Designation/Position Year (ref)
Health Canada DSL – low priority substance (already risk managed) 2006[35]
CEPA Schedule 1 and 6, paragraphs ‘b’ and ‘c’ 2011[36]
National Classification System for Contaminated Sites Rank: “High hazard” 2008[37]
Cosmetic Ingredient Hotlist Not permitted 2004[38]
National Pollutant Release Inventory (NPRI) Substance List NPRI Part (Threshold Category): 1B, Reportable to NPRI if manufactured, processed, or otherwise used at quantities greater than: 50 kg . Total of the pure element and the equivalent weight of the element contained in any cound, alloy or mixture. 2016[39]
DSL = Domestic Substance List
CEPA = Canadian Environmental Protection Act

Arsenic was not included in other Canadian government guidelines, standards, or chemical listings reviewed.

Main Uses

The major use for arsenic has been for chromated copper arsenate (CCA) in the wood preservation industry. In recent years, however, use patterns have changed.[40]

In December 2003, a voluntary agreement was made in the United States and Canada to stop using CCA in wood for residential applications, including play structures, decks, fencing, and boardwalks.[41] Prior to 2004, 90% of arsenic consumption in the US was for pressure treated wood; the figure reported for 2007 was 50%.[40] Marine timbers, plywood flooring and roofing, utility poles, and glue-laminated beams can still be treated with CCA.

There are several other current uses of arsenic. In the metallurgical industry, arsenic is used to harden copper and lead-antimony alloys; applications include ammunitions, solders, battery posts, bearings, and lead shot.[40] In glassmaking, arsenic is used to disperse bubbles or for colour.[2] In the semiconductor industry, high-purity arsenic is used in applications such as solar cells, light emitting diodes, lasers, and integrated circuits.[1]

Historically, arsenic has been included in agricultural chemicals, either directly or after conversion to arsenic acid, and was widely used as a pesticide and fertilizer. This is generally no longer permitted,[2] though arsenicals may be used in emergency situations (e.g. pine beetle infestation).[42] Until the 1970s, arsenic was used to treat leukemia, psoriasis, and asthma.[1] In the 1990s, there was renewed interest in using arsenic to treat a specific type of leukemia.[2]

Canadian Production and Trade

Arsenic is presently obtained as a byproduct of the smelting of copper, lead, cobalt, and gold ores.[43] In 2009, Hudson Bay Mining and Smelting was the base metal smelter with the largest emissions of arsenic in Canada accounting for 38% of emissions.[44] Other Canadian base metal smelters and refineries that produce and emit arsenic include: Vale Canada Ltd.-Copper Cliff, Vale Canada Ltd.-Thompson, Xstrata Copper-Horne, and Xstrata Copper-CCR.[44]

Production and trade

Activity Quantity Year
Export None 2015[35]
Import 58 t of ‘arsenic’ 2015[35]
t = tonne

Environmental Exposures Overview

Consuming arsenic through food is generally considered the primary route of exposure for the general population, although drinking water can also be a significant source in areas where arsenic is found in bedrock (thus contaminating drinking water sources).[45] Areas in Canada with arsenic-rich geologic deposits include the Yukon, Northern British Columbia (B.C.), Nunavut Islands, the Atlantic coast, and few hot spots in Southern Ontario.[46] CAREX Canada’s environmental estimates indicate that arsenic levels in Canadian drinking water result in higher risks of cancer at a population level (moderate data quality). Estimates for food and beverages show that arsenic exposure also results in an increased risk via this route (low data quality).

Quantifying the relative contribution of food and drinking water is difficult because arsenic uptake varies based on the form (i.e. organic or inorganic) and valence state of arsenic.[47] Based on limited available research,[48,49] intake of inorganic arsenic, which is considered more toxic, is estimated at 25% of total arsenic intake. In Canada, sources of arsenic in food include shellfish, meat, poultry, grain, and dairy products.[50] Arsenic has been found in bioaccessible forms (i.e. that can be readily absorbed) in Canadian wild plants and game, including berries, mushrooms, and hares.[51] In Ontario, 84% of the daily intake of arsenic was estimated to come from food, 15% from water, less than 1% from soils/dusts, and a negligible amount from skin contact.[50] This trend should be relatively similar across Canada. Arsenic in pigments and paints may be ingested through contaminated hands, fingernails, food, cups, or cigarettes.[1]

The average arsenic concentration in ambient air in 11 Canadian cities and one rural site in 1990 was 0.001 µg/m3.[47] Weathering and erosion of arsenic-containing rocks and soils contributes to natural levels of arsenic in the environment, however anthropogenic sources are the most significant contributors. Examples include mining base-metals and producing gold;[52] burning waste and coal;[53] leaching from arsenic treated sawdust and wood, or smoke from treated wood;[1] and applying arsenic-based pesticides.[54] Monosodium methanearsonate (MSMA), an arsenic-containing pesticide, was used in B.C. forests from 1995-2004 in an attempt to slow the pine beetle infestation.[40] When arsenic accumulation and behavioural changes in woodpeckers and other insect-feeding species were observed, MSMA was removed from B.C. markets.[55]

Some Canadian sites with high arsenic levels from mining/smelting residues include Moira Lake, ON, Yellowknife, NT, Bathurst, NB, and Rabbit Lake, SK.[54] Samples taken recently near Sydney, NS found 20% of background soil samples and 95% of tar pond soil samples were above Canadian health-based guidelines for arsenic in soil .[56]

Searches of Environment Canada’s National Pollutant Release Inventory (NPRI) and the US Household Products Database yielded the following results on current potential for exposure to arsenic in Canada:

NPRI and US Household Products Database

NPRI 2015[57]
Substance name: ‘Arsenic’
Category Quantity Industry
Released into Environment 152 t Foundries,
Non-ferrous metal (except aluminum)
production and processing,
metal ore mining (272 facilities)
Disposed of 23,889 t
Sent to off-site recycling 473 t
US Household Products 2015[58]
Search Term Quantity Product Type
‘Arsenic’ 6 Gear and motor oils (4), cement colorant (1), pet care lotion(1)
t = tonne

For more information, see the environmental exposure estimate for arsenic.

Occupational Exposures Overview

Inhalation and dermal contact are the most important routes of occupational exposure.[1]

CAREX Canada estimates that approximately 25,000 Canadians are exposed to arsenic at work; about half are exposed due to the use of arsenic in CCA wood preservatives. The industries with the highest number of exposed workers are foundation, structure, and building exterior contractors, as well as sawmills and wood preservation, and non-residential building construction. These workers are primarily exposed to arsenic through CCA treated wood. Workers are also exposed to arsenic in metal processing and manufacturing, oil and gas extraction, metal and ore mining, and water, sewage and other systems industries. Overall, larger numbers of exposed workers are employed in British Columbia and Quebec due to the large wood and wood product manufacturing industries in these provinces.

For more information, see the occupational exposure estimate for arsenic.


1. National Toxicology Program (NTP). 14th report on carcinogens for Arsenic Compounds, Inorganic (2016) (PDF)
2. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Arsenic (2005) (PDF)
3. International Agency for Research on Cancer (IARC). Monograph volume 23, Suppl. 7 (1987) (PDF)
4. US National Library of Medicine. Hazardous Substances Data Bank(HSDB) (Search term: ‘Arsenic’)
5. International Agency for Research on Cancer (IARC). Monograph summary, Volume 100C (2012) (PDF)
6. Agency for Toxic Substances and Disease Registry (ATSDR). ToxFAQs Sheet (2007) (PDF)
12. Government of Newfoundland and Labrador. Regulation 5,12 Occupational Health and Safety Regulations (2018)
13. Government of the Northwest Territories. Occupational Health and Safety Regulations, R-039-2015 (2020) (PDF)
15. The Canadian Legal Information Institute (CanLII). Government of Nunavut’s Occupational Health and Safety Regulations, Nu Reg 003-2016 (2010)
17. Government of Prince Edward Island. Occupational Health and Safety Act Regulations Chapter 0-1 (2013) (PDF)
19. Government of Saskatchewan. The Occupational Health and Safety Regulations, 1996 (2016) (PDF)
20. The Canadian Legal Information Institute (CanLII). Yukon’s Occupational Health Regulations, O.I.C. 1986/164 (2020) (PDF)
21. Occupational Safety and Health Administration (OSHA). Annotated PELs (2020)
22. The Canadian Legal Information Institute (CanLII). Regulation respecting the quality of drinking water, CQLR c Q-2, r 40 (2020)
23. Government of British Columbia. Source Drinking Water Quality Guidelines (2020) (PDF)
25. Government of Manitoba, Manitoba Water Stewardship. Manitoba Water Quality Standards, Objectives, and Guidelines (2011) (PDF)
27. The Canadian Legal Information Institute (CanLII). Ontario Drinking Water Quality Standards, O Reg 169/03 (2020)
28. Alberta Environment and Parks. Ambient Air Quality Objectives (2019)
29. Government of Manitoba. Ambient Air Quality Guidelines (2005) (PDF)
30. Ontario Ministry of the Environment and Climate Change. Ontario’s Ambient Air Quality Criteria (2019)
32. Government of Quebec. Clean Air Regulation, Q-2, r. 4.1 (2020)
33. Government of British Columbia. Contaminated Sites Regulation B.C. Reg. 375/96 (2019)
36. Environment and Climate Change Canada. CEPA List of Toxic Substances (2020)
37. Canadian Council of Ministers of the Environment. National Classification System for Contaminated Sites (PDF) (2008)
38. Health Canada. Cosmetic Ingredient Hotlist (2019)
40. US Geological Survey. Arsenic Yearbook (2007) (PDF)
43. Agency for Toxic Substances and Disease Registry (ASTDR). Toxicological profile for arsenic (2007) (PDF)
46. Grosz AE, Grossman JN, Garette R, Vowinkel E. “A preliminary geochemical map for arsenic in surficial materials of Canada and the United States” Appl Geochem 2004;19:257-260
48. Hazell T. “Minerals in foods: dietary sources, chemical forms, interactions, bioavailability.” World Review of Nutrition and Dietetics1985;46:1.
49. EPA (1988). Special report on ingested inorganic arsenic. Skin cancer; nutritional essentiality. Report No. EPA-625/3-87/013, Risk Assessment Forum, U.S. Environmental Protection Agency, Washington, DC.
50. Canadian Environmental Health Atlas. Arsenic
51. Koch I, Dee J, House K, Sui J, Zhang J, McKnight-Whitford A, Reimer KJ. “Bioaccessibility and speciation of arsenic in country foods from contaminated sites in Canada.” Sci Total Environ 2013;449(1).
54. Wang S, Mulligan C. “Occurrence of arsenic contamination in Canada: Sources, behaviour and distribution.” Sci Tot Environ2006; 366(2-3):701-721.
55. Morrissey C, Dods P, Elliott J. “Pesticide Treatments Affect Mountain Pine Beetle Abundance and Woodpecker Foraging Behavior.” Ecological Applications 2008;18(1):172-184.
57. Environment and Climate Change Canada. National Pollutant Release Inventory (NPRI) Facility Search (Substance name: ‘Arsenic’)
58. US National Library of Medicine. Household Products Database (HPD) (Search term: ‘Arsenic’)


Other Resources

  1. Leonardi G, Vahter M, Clemens F, Goessler W, Gurzau E, Hemminki K, Hough R, Koppova K, Kumar R, Rudnai P, Surdu S, Fletcher T. “Inorganic Arsenic and Basal Cell Carcinoma in Areas of Hungary, Romani, and Slovakia: A Case-Control Study.”Environ Health Perspect 2012; 120(5): 721-726
  2. US Environmental Protection Agency (EPA). Drinking Water Requirements for States and Public Water Systems
  3. Decke P, Cohen B, Butala J, Gordon T. “Exposure to Wood Dust and Heavy Metals in Workers Using CCA Pressure-Treated Wood.” Am Ind Hyg Assoc J 2002;63(2):166171.

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