1,3-Butadiene Profile

INDUSTRIAL CHEMICALS   KNOWN CARCINOGEN (IARC 1)

CAS No. 106-99-0
IARC Monograph Vol. 97, 2008 (Group 1)
IARC Monograph Vol. 100F, 2012 (Group 1)

1,3-Butadiene Profile

QUICK SUMMARY

  • A by-product of incomplete combustion of organic matter; produced commercially for industrial use
  • Associated cancers: Blood and lymphatic system cancers
  • Most important route of exposure: Inhalation
  • Uses: Found in synthetic elastomers (ex. in automobile tires), butadiene rubbers (ex. in rubber products, chewing gum), and styrene-butadiene latex (ex. in coated paper, flooring)
  • Occupational exposures: Approx. 4,000 Canadians are exposed at work, primarily in basic chemical, rubber, and plastic product manufacturing industries
  • Environmental exposures: Via combustion sources in indoor and outdoor air such as vehicle exhaust, cigarette smoke, cooking, heating, and forest fires
  • Fast fact: Newer vehicles with catalytic converters emit less 1,3-butadiene than older vehicles.

General Information

1,3-Butadiene is a non-corrosive colourless gas with an odour similar to that of gasoline.[1] It is emitted as a byproduct of incomplete combustion of organic matter, and is produced commercially for use in the chemical polymer industry.[2] 1,3-Butadiene may also be referred to as butadiene or vinylethylene.[3] There are numerous other synonyms and product names; see the Hazardous Substances Data Bank (HSDB) for more information.[3]

1,3-Butadiene has been classified by the International Agency for Research on Cancer (IARC) as Group 1, carcinogenic to humans, with sufficient evidence of carcinogenicity in humans.[4] 1,3-Butadiene causes cancer of the haematolymphatic organs, and this is also supported by sufficient evidence of carcinogenicity in animals.[4]

Concurrent exposure to other chemicals complicates analysis of additional adverse health effects related to 1,3-butadiene. However, cardiovascular and respiratory effects have been reported.[5] Low levels of exposure may result in sensory irritation while short term high levels may damage the central nervous system.[5] Dermal exposure to liquid 1,3-butadiene can cause irritation and frostbite.[5] Animal data indicates potential for reproductive effects, although there is as yet no evidence in humans.[6]

Regulations and Guidelines

Occupational Exposure Limits (OEL) [7,8,9,10,11,12,13,14,15,16,17,18,19,20,21]

Canadian Jurisdictions OEL (ppm)
Canada Labour Code 2
BC, AB, MB, NB, NS, NL, NT, ON, PE, QC 2
NU, SK 2
4 [stel]
YT 1000
1250 [stel]
Other Jurisdiction OEL (ppm)
ACGIH 2018 TLV 2
ppm = parts per million
stel = short term exposure limit (15 min. maximum)
ACGIH = American Conference of Governmental Industrial Hygienists
TLV = threshold limit value

Canadian Environmental Guidelines

Jurisdiction Limit Year
Cosmetics Hotlist Not Permitted 2014[22]
National Classification System for Contaminated Sites Rank= “High hazard”, confirmed human carcinogen 2008[23]
BC’s Contaminated Sites Regulation, BC Reg 375/96

Sets soil standards for the protection of human health:
Agricultural and low density residential sites: 2 μg/g
Urban park and high density residential sites: 4 μg/g
Commercial and industrial sites: 9.5 μg/g

Drinking water: 1 μg/L

Sets vapour standards for the protection of human health:
Agricultural, urban park, residential use standard: 2 μg/m3
Commercial use standard: 2 μg/m3
Industrial use standard: 3 μg/m3
Parkade use standard: 2.5 μg/m3

2017[24]
Ontario Ambient Air Quality Criteria Annual: 2 µg/m3
24-hour: 10 µg/m3
2016[25]

1,3-Butadiene was not included in other Canadian government environmental guidelines reviewed.[26,27,28]

Canadian Agencies/Organizations

Agency Designation/Position Year
Health Canada DSL – low priority substance (already risk managed) 2006[29]
CEPA Schedule 1, paragraphs ‘b’ and ‘c’ 1999[30]
Challenge to Industry Batch 2 2009[31]
Environment Canada’s National Pollutant Release Inventory Reportable to NPRI if manufactured, processed, or otherwise used at quantities greater than 10 tonnes or if released at quantities greater than 1 tonne of 10-tonne total VOC air release 2016[32]
DSL = domestic substance list
CEPA = Canadian Environmental Protection Act

Main Uses

1,3-Butadiene is used primarily to manufacture synthetic elastomers, including polybutadiene rubber used in automobile tires, vehicle parts, and appliance and electrical equipment components;[1] styrene-butadiene rubber used in rubber products[33] and chewing gum;[34] styrene-butadiene latex, used in coated paper, certain types of flooring, adhesives, and tire cord latex;[35] and nitrile-butadiene rubber, a copolymer of butadiene and acrylonitrile used in products that require oil resistance, such as hoses and belting.[36]

Polybutadiene is the largest end use of butadiene elastomers in Canada.[37] Production of acrylonitrile-butadiene-styrene (ABS) polymers in Canada ceased in 1994.[37]

Other uses include neoprene rubber, ABS resins, co-polymer resins and latexes for paints, coatings and adhesives, oil lubricant additives, and rocket propellants.[38] A non-polymer use is for producing adiponitrile, a nylon intermediate.[1]

1,3-Butadiene has also been used to produce the agricultural fungicides captan and captafol.[1]

Canadian Production and Trade

Styrene-butadiene latex is produced in a plant located in Varennes, Quebec.[35] A nitrile-butadiene plant was formerly located in Sarnia, but was recently closed.[38]

Production and Trade

Activity Quantity Year
Export 78,385 t of ‘buta-1,3-diene and isoprene’ 2015[39]
Import 4,371 t of ‘buta-1,3-diene and isoprene’ 2015[39]
t = tonne

Environmental Exposures Overview

The most important route of exposure for the general Canadian population is inhalation.[2]

CAREX Canada’s environmental estimates indicate that 1,3-butadiene levels in indoor air result in an increased lifetime risk of cancer at a population level (moderate data quality). Factors contributing to indoor levels of butadiene include cigarette smoke, proximity to a vehicle exhaust source (traffic or garage), cooking activity involving heated fats and oils (such as Chinese rapeseed, peanut, soybean and canola oils), wood burning, and natural gas/oil space heating.[2]

CAREX Canada estimates that levels of 1,3-butadiene in outdoor air may also result in an increased risk of cancer (high data quality). Factors contributing to levels in outdoor air include forest fires, vehicle emissions, aircraft, marine and rail transportation, waste incinerator emissions, and thermal breakdown of butadiene-based rubbers and plastics.[1,2] Newer vehicles with catalytic converters emit less 1,3-butadiene than older vehicles.[2]

Butadiene is not persistent in air and has an atmospheric half life of a few hours, depending on weather conditions.[2] Levels in ambient air have been measured at several sites across Canada since 1987.[40] Data published in 2006 indicates that the average 1,3-butadiene concentration from 2000-2003 was 0.22µg/m3 and 0.02 µg/m3 for urban and rural sites, respectively. The highest recorded 24-hour concentration was 2.58 µg/m3, measured near an industrial point source in Sarnia in 2001. Other industrial point sources where concentrations may be high include Yellowknife, Fort McMurray, Port Mellon, Montreal/Varennes, and Oakville. However, industrial emissions have declined since 2004.

There is currently little available data to indicate whether butadiene is present in drinking water, food, and soil in Canada.[2] The potential for butadiene to migrate to food from containers exists, but is expected to be minimal; this route of exposure is likely much less important than inhalation.[2]

Searches of environmental and consumer product databases yielded the following results on current potential for exposure to 1,3-butadiene in Canada:

NPRI and US Household Products Database

NPRI 2015[41]
Substance name: ‘1,3-Butadiene’
Category Quantity Industry
Released into Environment 26 t Manufacturing (basic chemical; resin, synthetic
rubber, and fibres; petroleum and coal product),
oil and gas extraction,
pulp, paper and paperboard mills (21 facilities)
Disposed of 0.049 t
Sent to off-site recycling 0.004 t
US Household Products 2016[42]
Search Term Quantity Product Type
‘butadiene’ 4 Roofing and cement adhesives
t = tonne

For more information, see the environmental exposure estimate for 1,3-butadiene.

Occupational Exposures

Inhalation is the most important route of occupational exposure.[1] The potential for exposure exists in petroleum refining, as well as during production of purified butadiene monomer, various butadiene-based rubber and plastic polymers, and rubber and plastic products, such as tyres, hoses and a variety of molded objects.[4]

CAREX Canada estimates that approximately 4,000 Canadians are exposed to 1,3-butadiene in their workplaces. The largest industrial groups exposed are chemical, rubber, and plastic product manufacturing industries. The largest exposure groups by occupation are machine operators in the rubber and plastic processing industry.

For more information, see the occupational exposure estimate for 1,3-butadiene.

Sources

1. National Toxicology Profile (NTP). 14th report on carcinogens for 1,3-butadiene (2016) (PDF)
3. US National Library of Medicine. Hazardous Substances Data Bank (Search term: ‘butadiene’)
4. International Agency for Research on Cancer (IARC). Monograph Vol. 100F 1,3-Butadiene (2012) (PDF)
5. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for 1,3-butadiene (2012) (PDF)
7. Occupational Safety and Health Administration (OSHA). Annotated PELs (2018)
12. Government of Newfoundland and Labrador. Regulation 5,12 Occupational Health and Safety Regulations (2012)
13. Government of the Northwest Territories. Occupational Health and Safety Regulations, R-039-2015 (2016) (PDF)
15. The Canadian Legal Information Institute (CanLII). Government of Nunavut’s Occupational Health and Safety Regulations, Nu Reg 003-2016 (2010)
18. Government of Prince Edward Island. Occupational Health and Safety Act Regulations Chapter 0-1 (2013) (PDF)
20. Government of Saskatchewan. The Occupational Health and Safety Regulations, 1996 (2016) (PDF)
21. The Canadian Legal Information Institute (CanLII). Yukon’s Occupational Health Regulations, O.I.C. 1986/164 (2012) (PDF)
22. Health Canada. Cosmetic Ingredient Hotlist (2014)
23. Canadian Council of Ministers of the Environment (CCME). National Classification System for Contaminated Sites (2008) (PDF)
24. Government of British Columbia. Contaminated Sites Regulation B.C. Reg. 375/96 (2017)
25. Government of Ontario. Ontario’s Ambient Air Quality Criteria (2016)
30. Environment and Climate Change Canada. CEPA List of Toxic Substances (2017)
33. CPI Product Profile, Camford Information Services: Styrene-butadiene rubber (1999)
34. US Food and Drug Administration (FDA). Food Additive Status List (2014)
35. CPI Product Profile, Camford Information Services: Styrene-butadiene latex (1999)
36. CPI Product Profile, Camford Information Services: Nitrile-butadiene rubbers (1999)
37. Agency for Toxic Substances and Disease Registry (ATSDR). Medical Management Guidelines for 1,3-Butadiene (2014)
38. Thomas net News. Lanxess Corporation Press release (2008)
39. International Trade Centre. TradeMap (Free subscription required)
41. Environment and Climate Change Canada. National Pollutant Release Inventory (NPRI) Facility Search (Substance name: ‘1,3-Butadiene’)
42. US Household Products Database (HPD). Household Products (Search term: ‘1,3-Butadiene’)

Other Resources

  1. US Environmental Protection Agency (EPA). Integrated Risk Information System (IRIS) Chemical Assessment Summary (2002) (PDF)
  2. Cheng H, et al. “1,3-Butadiene and leukemia among synthetic rubber industry workers: Exposure response relationships.”Chemico-Biological Interactions 2007;166(1-3):15-24.
  3. Sathiakumar N, Graff J, Macaluso M, Maldonado G, Matthews R, Delzell E. “An updated study of mortality among North American synthetic rubber industry workers.” Occup and Environ Med 2005;62:822-829.
  4. Hughes K, Meek ME, Walker M, Beauchamp R. “1,3-Butadiene: Exposure Estimation, Hazard Characterization, and Exposure- Response Analysis.” J of Toxicol Environ Health B: Crit Rev 2003;6(1):55-83.

Subscribe to our newsletters

The CAREX Canada team offers two regular newsletters: the biannual e-Bulletin summarizing information on upcoming webinars, new publications, and updates to estimates and tools; and the monthly Carcinogens in the News, a digest of media articles, government reports, and academic literature related to the carcinogens we’ve classified as important for surveillance in Canada. Sign up for one or both of these newsletters below.

CAREX Canada

Faculty of Health Sciences

Simon Fraser University
Harbour Centre Campus
2602 - 515 West Hastings St
Vancouver, BC  V6B 5K3
CANADA

© 2019 CAREX Canada