Lindane Profile

PESTICIDES  KNOWN CARCINOGEN (IARC 1)

CAS No. 58-89-9
IARC Monograph Vol. 20, Suppl. 7, 1987 (Group 2B)
IARC Monograph Vol. 113, 2017 (Group 1)

Lindane Profile

QUICK SUMMARY

  • A pesticide and persistent organic pollutant that was formerly used for public health purposes such as lice control
  • Associated cancer: Non-Hodgkin lymphoma
  • Most important route of exposure: Skin contact
  • Uses: Treatment for head lice and scabies; formerly used as an insecticide on fruit, vegetables, forest crops, livestock, hard wood logs and lumber, and seed grains
  • Occupational exposures: Of limited concern due to lindane’s restricted use
  • Environmental exposures: Via its use as a treatment for lice and scabies; approximately 10-35% of lindane can be absorbed dermally
  • Fast fact: Lindane use was severely restricted in 1999. By 2001 and 2004, use on livestock and on all remaining agricultural products, respectively, were prohibited.

General Information

Lindane is the common name for gamma-hexachlorocyclohexane (γ-HCH). Lindane is a persistent organic pollutant (POP) and is listed for elimination under the United Nations Environment Program (UNEP) Stockholm Convention on POPs.[1] In the past, lindane was used in agricultural settings and to treat lice in dogs.[2] Even though it is no longer used on a large scale, lindane can be found in market foods and Northern traditional foods due to long range transport and its environmental persistence.[3,4] According to Health Canada’s Drug Product Database, all uses (both veterinary and human) have been cancelled in Canada.[5]

HCH is a synthetic chemical with eight isomers (chemical forms).[6] Technical grade-HCH is a mixture of several isomers, one of which is lindane (as 10-15% of the mixture).[6,7] Lindane is a white to brown solid that dissolves in water.[8] There are numerous other synonyms and product names; see the Hazardous Substances Data Bank (HSDB) for more information.[7]

In June 2015, the International Agency for Research on Cancer (IARC) classified lindane as carcinogenic to humans (Group 1).[9] This classification was based on sufficient evidence of carcinogenicity in humans for non-Hodgkin lymphoma in both occupational and non-occupational settings. There was also sufficient evidence that lindane can cause cancer in laboratory animals, and strong evidence that lindane can suppress the immune system in humans.[9]

Acute exposures to lindane target the nervous system and can lead to hyperexcitability, seizures, convulsions, vomiting, and nausea, as well as blood disorders and changes in hormone levels in the blood.[6]

Regulations and Guidelines

Occupational Exposure Limits (OEL)

Canadian Jurisdictions OEL (mg/m3) Notes
Canada Labour Code[10] 0.5 TWA, sk
AB[11], BC[12], ON[13], MB[14], NB[15], NL[16], NS[17], PE[18], QC[19] 0.5 TWA, sk
NT[20], NU[21], SK[22], YT[23] 0.5
1.5
TWA, sk
stel, sk
Other Jurisdiction OEL (mg/m3) Notes
ACGIH 2018 TLV[24] 0.5 TWA, sk
TWA = time weighted average (8 hours)
stel = short term exposure limit (15 min. maximum)
sk = Easily absorbed through the skin
ACGIH = American Conference of Governmental Industrial Hygienists
TLV = threshold limit value

Canadian Environmental Guidelines

Jurisdiction Limit Year
Ontario Ambient Air Quality Criteria 5 µg/m3 2016[25]
Ontario Drinking Water Guidelines 0.004 mg/L 2006[26]
US EPA Drinking Water Guidelines 0.0002 mg/L 1992[27]
WHO Drinking Water Guideline 0.002 mg/L 2011[28]
Health Canada’s Cosmetic Ingredient
Hotlist
Not Permitted 2015[29]
CCME National Classification System for Contaminated Sites Rank: High priority 2008[30]
Agreement Respecting the Great Lakes Basin Ecosystem Sets a limit of 0.01 µg/L for the protection of aquatic life
Sets a limit of 0.3 µg/g (wet weight) of edible portions of fish for the protection of humans
1978[31]
BC’s Contaminated Sites Regulation For the protection of human health, sets soil standards for:
Agricultural and low density residential sites= 10 µg/g
Urban park and high density residential sites= 25 µg/g
Commercial sites= 75 µg/g
Industrial sites: 250 µg/g
Drinking water standards= 0.15 µg/L
2017[32]
µg/m3 = micrograms per cubic metre
ppm = parts per million
mg/L = milligrams per litre
CCME = Canadian Council of Ministers of the Environment
µg/L = micrograms per litre
µg/g = micrograms per gram
* except for peas, rutabaga, and soybean, which have an MRL=0.1 ppm

Lindane was not included in other Canadian government environmental guidelines reviewed.[33,34,35,36,37,38,39,40]

Canadian Legal Status[41,42]

Jurisdiction Legislation Notes
International UNEP Stockholm Convention on POPs Establishes obligations for restricting or eliminating global production and use of toxic and persistent chemicals with high potential to bioaccumulate. In 2005, lindane was nominated and deemed acceptable to be included in this list of POPs
Federal Pest Control Products Act, SC 2002, c 28 De-registered for agricultural pest control uses, including veterinary uses; production, import, and use of lindane is prohibited in these circumstances
Provincial/Territorial    
AB Pesticide (Ministerial) Regulation, Alta Reg 43/1997 As a fumigant or air suspension: prohibited use unless certified or supervised, prohibited sale unless properly registered, and record of sales mandatory
BC Drug Schedules Regulation, BC Reg 9/98 May be sold by a pharmacist on a non-prescription basis; must be retained within the Professional Service Area of the pharmacy where there is no public access
MB, NB, NS, NL, NU, NT, ON, PE, SK, YU Legislation specific to lindane has not been passed
QC Regulation respecting the terms and conditions for the sale of medications, CQLR c P-10, r 12 Specifies how lindane can be sold as treatment for killing lice or scabies in humans
UNEP = United Nations Environment Program
POPs = Persistent Organic Pollutants

Main Uses

In the past, lindane was used as an insecticide on fruit, vegetables, forest crops, livestock, hardwood logs and lumber, and seed grains.[6,8] In Canada, lindane was primarily used on canola and corn crops.[43] As of 1999, lindane use was severely restricted, and by 2001 and 2004, use on livestock and on all remaining agricultural products, respectively, were prohibited.[43] In 2002, a topical cream containing lindane that had been marketed in Canada for dogs was removed from the Canadian market.[2]

Lindane was used solely as a second-line control measure for head lice and scabies under an exemption from the Food and Drugs Act, which expired on April 4, 2016. The phase out of lindane-based pharmaceuticals – which involves disposing of remaining stockpiles of lindane and products containing it in an environmentally sound way – should be ongoing or nearly complete.[44]

Canadian Production and Trade

Lindane has not been produced or manufactured in Canada since 1972.[3]

Total global use of lindane between 1948 and 1993 is estimated at 720,000 tonnes.[45] In the 1990s, lindane was one of the top ten insecticides used in Canada. After that, lindane use significantly decreased, with 500 tonnes being used in 2000.[45]

Up until 2001, an estimated 500 metric tons of pesticide products containing lindane were exported annually by the United States (primarily to Canada).[6] However, in January 2005, lindane was de-registered for use in agricultural pest control, after which the import and sale of lindane was prohibited.[44]

Environmental Exposures Overview

Environmental Fate

Lindane does not occur naturally. Although it does biodegrade, the process is slow and therefore lindane persists after being introduced to the environment through human activities.[6]

Lindane may be found in air, soil, sediments, and water.[6] It generally has low solubility in water, is volatile from soil and water, has low potential mobility in soil due to high adsorption, and has the potential to bioaccumulate.[4]

Volatilization from soil is the most important route of dissipation for lindane.[4] As a vapour in the air it attaches to dust particles, on which it can persist and travel long distances depending on the season and weather conditions.[3,6] Another major source of lindane in the air is fugitive dust particles released as wind erodes contaminated soil.[3] Contaminated particles are gradually broken down and removed by rain or other compounds found in the atmosphere.[6]

Persistent organic pollutants (POPs) including lindane were found at high concentrations in the Arctic in the 1980s. Lindane was transported to these regions through atmospheric deposition and ocean currents.[3] Fortunately, levels of lindane in the food web and air have since decreased; this trend accelerated in 2002, coinciding with increased restrictions on lindane in Canada.[46]

Exposure Pathways

The general public may be exposed to lindane through dermal absorption, ingesting contaminated foods, breathing contaminated air, or being in contact with contaminated soil or water.[6] Lindane is metabolized into many other substances, including chlorophenols, some of which have toxic properties.[6]

Dermal absorption is an important route of exposure given that lindane was formerly used to treat lice and other parasites. Dermal absorption typically varies between 10-35%, although some studies measured absorption values as low as 9% and up to 100%. Absorption depends on the pesticide formulation and skin characteristics of the person exposed.[4] There is a 20-fold variation in absorption reported for children due to an increased surface area to volume ratio.[4,6]

Lindane bioaccumulates in the fat tissues of organisms.[3] Foods with the greatest potential to contain and transfer lindane therefore include milk, eggs, other dairy products, and some seafood. Pickles and raw mushrooms may also contain high concentrations of lindane.[8] Exposure can occur via lindane residues on food products or accumulation in animal tissue. Lindane has also been found in breast milk.[6]

Northern Aboriginal peoples are more likely to experience potential health effects resulting from lindane bioaccumulating in traditional foods.[4] The majority of Aboriginal households (90%) in the Northwest Territories report consuming traditional foods such as harvested wildlife and or marine mammals.[3]

CAREX Canada estimates that less than one extra cancer per million individuals occurs due to exposures through diet (including drinking water and foods and beverages), indicating that exposure through this route does not result in an increased risk of cancer (very low data quality).

CAREX Canada also estimates that lindane levels in outdoor air (moderate data quality) and indoor dust (low data quality) do not result in an increased risk of cancer. However, we estimate that lindane concentrations in indoor air do result in an increased risk of cancer (very low data quality).

Lindane releases are not reportable to the National Pollutant Release Inventory (NPRI).[47] No consumer products containing lindane were found in the US Household Products Database.[48]

For more information, see the environmental exposure estimate for lindane.

Occupational Exposures Overview

Inhalation, dermal contact and ingestion are all potential routes of occupational exposure.[8]

In the past, workers were exposed to lindane through mixing, loading, or applying the pesticide during seed treatment and when handling and planting treated seed.[4] However, since lindane use has been phased out, occupational exposures to lindane are no longer a concern in Canada.

Sources

Photo: Flickr, Gilles San Martin

4. Health Canada. Lindane Risk Assessment (2009) (PDF)
5. Health Canada. Drug Product Database (2015)
6. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Hexachlorocyclohexane (2005) (PDF)
7. US National Library of Medicine. Hazardous Substances Data Bank (Search term: ‘lindane’)
9. International Agency for Research on Cancer (IARC). IARC Monographs, Volume 113 (2017) (PDF)
16. Government of Newfoundland and Labrador. Regulation 5,12 Occupational Health and Safety Regulations (2012)
18. Government of Prince Edward Island. Occupational Health and Safety Act Regulations Chapter 0-1 (2013) (PDF)
20. Government of the Northwest Territories. Occupational Health and Safety Regulations, R-039-2015 (2016) (PDF)
21. The Canadian Legal Information Institute (CanLII). Government of Nunavut’s Occupational Health and Safety Regulations, Nu Reg 003-2016 (2010)
22. Government of Saskatchewan. The Occupational Health and Safety Regulations, 1996 (2016) (PDF)
23. The Canadian Legal Information Institute (CanLII). Yukon’s Occupational Health Regulations, O.I.C. 1986/164 (2012) (PDF)
24. Occupational Safety and Health Administration (OSHA). Annotated PELs (2018)
25. Ontario Ministry of the Environment and Climate Change. Ontario’s Ambient Air Quality Criteria (2016)
26. The Canadian Legal Information Institute (CanLII). Ontario Drinking Water Quality Standards, O Reg 169/03 (2017)
27. US Environmental Protection Agency (EPA). Table of Regulated Drinking Water Contaminants (2016)
29. Health Canada. Cosmetic Ingredient Hotlist (2015) (PDF)
30. Canadian Council of Ministers of the Environment (CCME). National Classification System for Contaminated Sites (2008) (PDF)
31. International Joint Commission. Revised Great Lakes Water Quality Agreement of 1978 (1978) (PDF)
32. Government of British Columbia. Contaminated Sites Regulation B.C. Reg. 375/96 (2017)
34. Government of Canada. List of all Challenge substances (2009)
35. Environment and Climate Change Canada. Toxic Substances List – Schedule I (2013)
39. Alberta Environment and Parks. Ambient Air Quality Objectives (2017)
41. The Canadian Legal Information Institute (CanLII). The Canadian Legal Information Institute (CanLII) website
45. Indian and Northern Affairs Canada. Sources, Occurence, Trends and Pathways in the Physical Environment (2003) (PDF)
46. Riget F, Bignert A, Braune B, Stow J., and Wilson S. “Temporal trends of legacy POPs in Arctic biota, an update.” Sci Tot Environ2010;408:2874-2884. doi: 10.1016/j.scitotenv.2009.07.036
47. Environment and Climate Change Canada. National Pollutant Release Inventory (NPRI) Facility Search (Search term: ‘Lindane’).
48. US Household Products Database (HPD). Household Products (Search term: ‘Lindane’)

Other Resources

  1. Vijgen J.The Legacy of Lindane HCH Isomer Production. International HCH & Pesticides Association (2006) (PDF)
  2. US Environmental Protection Agency (EPA). Technology Transfer Network, Lindane (Gamma-Hexachlorocyclohexane) (2000)
  3. Stockholm Convention. Persistent Organic Pollutants Review Committee: Information submitted for Lindane (list of documents)(2008)

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