Dichloromethane is a volatile, clear, and colourless liquid with a smell similar to chloroform. It has been an important industrial solvent since the 1940s. Dichloromethane is also commonly referred to as methylene chloride and DCM. There are numerous other synonyms and product names; see the Hazardous Substances Data Bank (HSDB) for more information.
Dichloromethane is classified by the International Agency for Research on Cancer (IARC) as Group 2A, probably carcinogenic to humans, based on limited evidence that it causes biliary-tract cancer and non-Hodgkin lymphoma in humans, and sufficient evidence of carcinogenicity in experimental animals (malignant lung and hepatocellular tumours in male and female mice). This assessment also considered the strong mechanistic evidence that dichloromethane is broken down into reactive metabolites by an enzyme called glutathione-S-transferase T1 (GSTT1), and that this activity is strongly associated with genotoxicity in vitro and in vivo.
The central nervous system is the primary target of acute inhalation exposure. Respiratory effects and skin irritation have also been reported.
Included under product aerosol recommendations (adequate ventilation and intermittent used advised)
Cosmetic Ingredients Hotlist
Not permitted in aerosol preparations (as "methylene chloride")
Food Additives Permitted for Use
CE – Carriers or Extraction Solvents
BC's Contaminated Sites Regulation, BC Reg 375/96
Sets soil standards for the protection of human health:
Agricultural and low density residential sites: 250 μg/g
Urban park and high density residential sites: 500 μg/g
Commercial sites: 1,500 μg/g
Industrial sites: 40,000 μg/g
Sets vapour standards for the protection of human health:
Agricultural, urban park, residential use standard: 600 μg/m3
Commercial use standard: 2,000 μg/m3
Industrial use standard: 5,500 μg/m3
Parkade use standard: 5,000 μg/m3
mg/L = milligrams per litre
µg/m3= micrograms per cubic metre
µg/g = micrograms per gram
Dichloromethane was not included in other Canadian government environmental guidelines reviewed.
National Classification System for Contaminated Sites
Rank = "High hazard", potential human carcinogen
Environment Canada's National Pollutant Release Inventory
Reportable to NPRI if manufactured, processed, or otherwise used at quantities greater than 10 tonnes
Dichloromethane was not included in other Canadian government chemical listings reviewed.
DSL = domestic substance list
CEPA = Canadian Environmental Protection Act
Dichloromethane is used to strip paint and remove varnish. It has also been used as a flexible urethane blowing agent, in aerosol formulations, as a solvent in producing pharmaceuticals and film coatings, and as an extraction medium (used in the food industry to extract spices, caffeine, and hops).[2,5] Other uses include degreasing metals, manufacturing electronics and adhesives, processing plastics, and refrigerating.[5,34]
Historically, dichloromethane has been used as a fumigant. However, it is not currently registered as a pest-control product in Canada.
Canadian Production and Trade
Canada does not produce dichloromethane, but meets domestic requirements through imports.
Production and Trade
Not produced since 1985
89 t of 'dichloromethane (methylene chloride)'
3,064 t of 'dichloromethane (methylene chloride)'
t = tonne
Inhalation is the most important route of occupational exposure, however dermal absorption is also possible.
CAREX Canada estimates that approximately 25,000 Canadians are exposed to dichloromethane in their workplace. The largest industrial groups exposed are automotive repair and maintenance, followed by building finishing contractors and plastic product manufacturers. Other important industries that are likely exposed include paint removal, personal and household goods maintenance and repair, and automotive parts manufacturing.
The largest exposed occupational groups are motor vehicle body repairers, followed by painters and decorators, and machinists and machining and tooling inspectors. Other occupations that may be exposed include furniture refinishers and chemical manufacturers. Workers may be exposed when spraying urethane foam, removing paint or varnish from equipment or furniture, or using products that use dichloromethane as a propellant or degreasing agent.
An estimated 80% of dichloromethane produced globally is released to the environment.
Based on data gathered in the early 1990's, indoor air is likely the most significant source of exposure for Canadians. CAREX Canada's environmental estimates indicate that dichloromethane levels in indoor air result in an increased risk of cancer (moderate data quality).
Ambient air may be of greater concern in industrialized urban areas and in close proximity to waste or disposal sites.[2,39] CAREX Canada's environmental estimates indicate that dichloromethane levels in outdoor air do not result in an increased risk of cancer (high data quality).
Environment Canada estimated that 2 million people were exposed to dichloromethane by using consumer products including paint strippers, aerosol paints, and insecticides and cleaning solutions. Data on levels of dichloromethane in food is limited; however, it has been detected in several products including cereal and butter.[40,41] Potential for bioaccumulation in foods is low. Dichloromethane levels are below the detection limit in the majority of drinking water samples collected in Canada, and are more frequently associated with groundwater sources.[41,42] Total daily intakes of dichloromethane for the Canadian general population are estimated to range from 3.96 to 6.62 micrograms/kilogram of body weight per day. No recent Canadian studies have been identified for dichloromethane estimates in food and beverages.
Soil data on dichloromethane levels is limited to contaminated sites.[40,41] Dichloromethane has been detected in groundwater in Canada, and is usually associated with nearby landfills and waste disposal sites.
Searches of the National Pollutant Release Inventory (NPRI) and US Household Products Database yielded the following results on current potential for exposure to dichloromethane in Canada:
NPRI and US Household Products Database
Search term: 'dichloromethane'
Released into Environment
Office furniture manufacturing, pharmaceutical and chemical manufacture, pulp and paper mills, paint, coating and adhesive manufacturing (24 facilities)
Sent to off-site recycling
US Household Products 2015
Heavy-duty automotive cleaners and degreasers (11), paint and adhesive remover (39), paint brush cleaner (2), furniture cleaner (1), deglosser (1), and herbicide (1)
t = tonne
Our team has performed a detailed scan of exposure control resources and assembled a compilation of key publications and resources. These are organized by type of exposure (environmental or occupational) and by specificity (general or carcinogen-specific). Please visit our Exposures Reduction Resources page to view.
We also recommend exploring the Prevention Policies Directory, a freely-accessible online tool offering information on policies related to cancer and chronic disease prevention. Providing summaries of the policies and direct access to the policy documents, the Directory allows users to search by carcinogen, risk factor, jurisdiction, geographical location, and document type. Click here to learn more about policies specific to dichloromethane in the Directory. For questions about this resource, please contact a member of the Prevention Team at the Canadian Partnership Against Cancer at email@example.com.