Cobalt Sulfate and Other Soluble Cobalt (II) Salts (Group 2B)
Cobalt is a naturally-occurring, silvery-grey magnetic metal with properties similar to iron and nickel. Small amounts of cobalt are found in most rocks, soil, water, and organisms. It is usually combined with oxygen, sulphur, or arsenic. Vitamin B12, a cobalt-containing compound also referred to as cobalamin, is an important dietary nutrient. Cobalt has several radioisotopes, two of which are commercially important (60Co, 57Co). There are numerous other synonyms and product names for cobalt; see the Hazardous Substances Data Bank (HSDB) for more information.[4,5,6]
Cobalt and its compounds were classified by the International Agency for Research on Cancer (IARC) in 1991 as Group 2B, possibly carcinogenic to humans. This classification was based on inadequate evidence in humans linking exposure and lung cancer, but limited or sufficient evidence in animals for some specific cobalt compounds. In 2006, IARC classified cobalt metal with tungsten carbide in powders, hard metals, or sintered carbides as Group 2A, probably carcinogenic to humans. Recent epidemiological studies of hard metal workers in France and Sweden reported increased lung cancer rates in workers exposed to cobalt with tungsten carbide. However, more conclusive epidemiological evidence or strong mechanistic evidence are required to establish a causal link.
The 2006 monograph also evaluated cobalt metal without tungsten carbide, as well as cobalt sulfate and other soluble cobalt (II) salts, which remain in Group 2B. Increased cancer risk has been reported for work with cobalt compounds without tungsten carbide, however these studies were limited by small numbers and lack of control for confounding variables.
Respiratory effects of chronic occupational exposure to cobalt are well documented. Cobalt is likely the primary contributor to health effects associated with hard metal welding. These range from irritation, decreased pulmonary function, and asthma to hard metal lung disease involving pneumonia and fibrosis. Cardiovascular effects are also reported from inhalation exposures. Cobalt exposure can result in skin sensitization and allergic dermatitis.
stel = short term exposure limit (15 min. maximum)
s = sensitizer
ACGIH = American Conference of Governmental Industrial Hygienists
TLV = threshold limit value
Canadian Environmental Guidelines
Ontario Ambient Air Quality Criteria
24-hour: 0.1 µg/m3
µg/m3 = micrograms per cubic meters
Cobalt and its inorganic compounds were not included in the Canadian government environmental guidelines reviewed.[23,24,25,26,27,28]
DSL – high priority substance with the greatest potential for exposure
Batch 10 Challenge to Industry For cobalt, cobalt chloride, cobalt sulfate
PMRA list of formulants
List 4B: contains formulants, some of which may be toxic, for which there
are sufficient data to reasonably conclude that the specific use pattern of
the pest control product will not adversely affect public health and the environment.
DSL = domestic substance list
CEPA = Canadian Environmental Protection Act
Cobalt and its compounds were not included in other Canadian government chemical listings reviewed.
The Cobalt Institute (CI) outlines the use of cobalt in: high-quality, corrosion-resistant metal alloys; in hard and soft magnetic alloys and materials; as a binding agent in cutting and drilling tools; and as a component in batteries, pigments, electronics, and medicine. Further uses of cobalt are outlined on the CI's webpage.[33,34]
The distribution of cobalt use in the US in 2006 was as follows: 49% superalloys (mainly for aircraft gas turbine engines); 9% in cemented carbide; 18% other metallic applications; 24% chemical applications.
Two cobalt radioisotopes, 60Cobalt and 57Cobalt, have commercial uses. 60Cobalt is used in cancer treatment, sterilization of medical and consumer products, food irradiation, and non-destructive testing. 57Cobalt is also used in scientific research.
Canadian Production and Trade
There are several Cobalt mining and refinery operations currently operating in Canada. Vale produced 1,362 t of refined cobalt metal at its Port Colborne refinery in Ontario in 2014. Vale's cobalt originated from company-owned nickel sulfide mines at Sudbury (Ontario), Thompson (Manitoba), and Voisey's Bay (Labrador). Glencore reported that 800 t of the cobalt produced at its Nikkelverk refinery in Norway originated from concentrates produced from its mines in Sudbury and Raglan (Quebec). The Fort Saskatchewan refinery in Alberta, a joint venture of Sherritt and General Nickel Co. S.A., produced 3,210 t of cobalt as metal powder and briquettes in 2014.
In 2015, Canada was responsible for 6.3% of global cobalt mine production and was ranked as the third largest global cobalt mine producer.
Production and Trade
0 t of 'cobalt ores and concentrates'
3 t of 'cobalt ores and concentrates'
1 t of ''cobalt oxides and hydroxides
0 t of ''cobalt oxides and hydroxides
t = tonne
Dusts and fumes containing cobalt may enter the respiratory tract, making inhalation the most important route of occupational exposure.
CAREX Canada estimates that approximately 33,000 Canadians are exposed to cobalt in their workplace. The main industrial groups exposed are in sawmills and wood preservation, medical equipment manufacturing, and metalworking machinery manufacturing. The largest occupational groups exposed include workers involved in producing or using metal cutting, grinding, or sharpening tools, followed by welders and dental technicians.
Additional occupations that may also be exposed to cobalt (including potential dermal exposure) are workers involved in: metal mining, smelting and refining; cobalt dye painting and cobalt chemical production: diamond polishing; glassware/porcelain work; offset printing; goldsmithing; and rockwool insulating.[2,39]
Workers involved in producing or handling radioactive forms of cobalt, such as those at nuclear or irradiation facilities, medicine/research or waste storage sites, are regulated and monitored under Health Canada's Radiation Protection Bureau. Exposure to radioisotopes is addressed under the CAREX carcinogen profile for Ionizing Radiation.
The vast majority (99%) of the general population's cobalt intake is estimated to be from food. Cobalt in dietary sources results from soil uptake by plants, and also from vitamin B12. Other sources include drinking water, vehicle exhaust, and tobacco smoke.
Anthropogenic sources make up the majority of emissions. These include fossil fuel burning, sewage sludge, phosphate fertilizers, mining and smelting of cobalt ores, processing of cobalt alloys, and industries that use or process cobalt compounds.
Natural sources of cobalt released into the environment include wind-blown dust, sea water spray, volcanoes, and forest fires. The mean atmospheric cobalt levels at unpolluted sites are generally <1 to 2 nanograms/m3 (ng/m3). Levels near industrial sources of cobalt may exceed 10 ng/m3.
Searches of Environment Canada's National Pollutant Release Inventory (NPRI) and the US Household Products Database yielded the following results on current potential for exposure to cobalt in Canada:
NPRI and US Household Products Database
Substance name: 'Cobalt and its compounds'
Released into Environment
Mining, water, sewage and other systems, motor vehicle manufacturing (96 facilities)
Sent to off-site recycling
t = tonne
US Household Products 2015
'Cobalt and its compounds'
Paints, glazes, and stains
Our team has performed a detailed scan of exposure control resources and assembled a compilation of key publications and resources. These are organized by type of exposure (environmental or occupational) and by specificity (general or carcinogen-specific). Please visit our Exposures Reduction Resources page to view.
We also recommend exploring the Prevention Policies Directory, a freely-accessible online tool offering information on policies related to cancer and chronic disease prevention. Providing summaries of the policies and direct access to the policy documents, the Directory allows users to search by carcinogen, risk factor, jurisdiction, geographical location, and document type. Click here to learn more about policies specific to cobalt in the Directory. For questions about this resource, please contact a member of the Prevention Team at the Canadian Partnership Against Cancer at firstname.lastname@example.org.